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Bespoke diets based on gut microbes could help beat disease and obesity
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In the last part of the study, the researchers trained a computer algorithm on their data and found that it could accurately predict how different people would respond to particular meals. To test the algorithm, Segal and Elinav used it to draw up bespoke diets for 20 pre-diabetic people. In the small trial each patient was given two very different diets. In the first week, their diet was tailored to minimise spikes in their blood glucose levels. In the second week, their diet was designed to have the same calorie content, but not to control their blood sugar. In many cases, he said, the tailored diets included foods that some might find surprising. For example, many people had low glucose responses to ice cream, and bread and butter tended to trigger less of a glucose response than unbuttered bread.
But in the next few months, the scientists will launch a much larger trial to see how effective tailored diets might be.